Advances in echocardiographic imaging technology, in particular, 2D strain analysis, have enabled noninvasive evaluation of left atrial (LA) function ( 5). The majority of previous studies in c-ToF have mainly focused on the assessment of right and left ventricular function and ventriculo–ventricular interaction with limited attention to atrial function ( 4). Although the overall survival of ToF has significantly improved with early surgical repair, long-term cardiac sequelae after corrected ToF (c-ToF), including chronic pulmonary regurgitation, biventricular dysfunction, life-threatening arrhythmias (LTA) and sudden cardiac death, persist ( 2, 3). Tetralogy of Fallot (ToF) represents the most common cyanotic heart defect at birth, accounting for 10% of all congenital cardiac defects ( 1). Further study is needed to determine how best to incorporate LA strain, particularly LA compliance, into multiparametric predictive models for LTA in c-ToF patients. Among the echocardiographic parameters, LA compliance was moderately inversely correlated with RV end-diastolic area ( r = −0.40, p = 0.01).Ĭonclusion: We documented abnormal LAS and LA compliance values in adult c-ToF patients. Moderate inverted correlations were found between LA compliance and age and QRS duration. LA compliance was the best echocardiographic predictor for h-LTA (AUC: 0.839 p < 0.001). Indexed LA and RA volumes, RV end-diastolic area was significantly higher and RV fractional area change significantly lower in the h-LTA group. LV ejection fraction, LAS and LA compliance were significantly lower in the group of patients with h-LTA. Results: Patients with h-LTA were older and exhibited a longer QRS duration. In addition to a 2D standard echocardiography examination, 2D strain analysis was performed to assess left ventricular (LV) and LA functions, including peak-positive LA strain (LAS-reservoir function) and LA compliance. Methods: Fifty-one c-ToF patients (34 males age, 39 ± 15 years h-LTA, n = 13) were included in this retrospective monocenter study. Objectives: The objectives of this study were to examine left atrial (LA) function and compliance using two-dimensional (2D) strain analysis in adult patients with corrected Tetralogy of Fallot (c-ToF) and to investigate the relationships between LA function and patient characteristics, especially history of life-threatening arrhythmia (h-LTA).
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